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Optimal design of a multi-product batch plant - ScienceDirect

Jan 01, 1998  A convex MINLP model for the preliminary design problem of a multi-product batch plant is developed. The plant model consists of several batch and

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Design of Multiproduct Batch Plants with Units in Series ...

Jan 16, 2009  MILP reformulations for the design of biotechnological multi-product batch plants using continuous equipment sizes and discrete host selection. Computers Chemical

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Design of multiproduct batch plants with uncertain demands ...

Jun 11, 1995  The benefits of the application of the global optimization approach for the design of multiproduct batch plants with uncertain demands will be illustrated in the

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Detailed Design of Multiproduct Batch Plants Considering ...

A convex MINLP model for the preliminary design problem of a multi-product batch plant is developed. The plant model consists of several batch and

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(PDF) DESIGN AND PRODUCTION PLANNING OF MULTIPRODUCT

A two-stage stochastic multiperiod LGDP (Linear Generalized Disjunctive Programming) model has been developed for the overall production planning and design of

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Optimal Design of Multiproduct Batch Plants under ...

Oct 27, 2008  In this study, we have introduced a fuzzy decision-making approach to design a multi-objective optimal design problem of a multiproduct batch chemical plant.

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MILP reformulations for the design of biotechnological ...

Jan 04, 2016  Conventional multi-product batch process literature using an optimization-based approach model the design and synthesis of such plants with Mixed-Integer

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(PDF) Optimal production strategy and design of ...

Figure 2 .Figure 3 .23Operating scheme of a multiproduct batch plant performing single-product campaigns (a distinct time-limiting stage per campaign). Operating

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Design and retrofit of multiobjective batch plants via a ...

Dec 15, 2003  Muliti-product and multi-purpose batch plants: Five products, 14 production routes: The objective of this paper is to present an alternative methodology based

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Optimal design of multi-purpose batch chemical plants ...

Apr 01, 1989  A review and future prospects of optimal design and operation has been published by Rippin (1983). Batch chemical plants can be classified into two classes:

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Design of Multiproduct Batch Plants with Units in Series ...

Jan 16, 2009  MILP reformulations for the design of biotechnological multi-product batch plants using continuous equipment sizes and discrete host selection. Computers Chemical Engineering 2016, 84, 1-11. DOI: 10.1016/jpchemeng.2015.08.001. Marta S. Moreno, Jorge M. Montagna. Multiproduct batch plants design using linear process performance models.

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Design of multiproduct batch plants under demand ...

This paper addresses the staged capacity expansion of multiproduct batch plants operating in single product campaign (SPC) mode and in the presence of product demand uncertainty. This extends previous work by the authors on the design problem.

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Design of Multiproduct Batch Plants under Demand ...

product demand realizations and capacity expansions, in the form of additional units of equal size, occur at the end of each period. The design objective, as stated above, suggests that a batch plant design and expansion policy is sought which establishes an optimal level of product demand satisfac- tion.

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Optimization of a biotechnological multiproduct batch ...

The design of multi-product batch plants using an optimization-based approach has been studied for more than 40 years and different approaches to deal with the complexity of the optimization models that result in non-convex mixed-integer non-linear problems (MINLP) goes from the development of new

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(PDF) Optimal production strategy and design of ...

Figure 2 .Figure 3 .23Operating scheme of a multiproduct batch plant performing single-product campaigns (a distinct time-limiting stage per campaign). Operating scheme of a multiproduct batch plant producing products P , and P2 simultaneously a t a ratio of 1:l (example 2 ) Model 4. 1 .1Problem Constraints. 4.1.1.

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Multiobjective Multiproduct Batch Plant Design Under ...

Abstract The design of batch plants necessary involves how equipment may be utilized, which means that plant scheduling and production must form an integral part of the design problem. The market demand for such products is usually changeable, and at the stage of conceptual design of a batch plant, it is almost impossible to obtain the precise information on the future product demand over the ...

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Optimization of multi-product batch plant design under ...

Mar 17, 2009  This paper presents a framework for the design and optimization of multi-product batch processes under uncertainty with environmental considerations. The uncertainties and environmental impacts are discussed. The profit and environmental impacts are considered as bi-objectives for batch plant design. The problem, thus, is formulated as a multi-objective stochastic

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Design of single-product campaign batch plants under ...

fications involving multiple processing steps in the same pro- cessing plant (Rippin, 1993). In this article, we consider the optimal design of multiproduct batch plants operating in sin- gle-product campaign (SPC) mode under product demand uncertainty. The defining feature of the SPC production mode

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Multi-Product Biopharmaceutical Manufacturing Facilities ...

Overall guidance for bringing new products into the facility Strategy for Establishing Routine Controls in Multi-Product Manufacturing Facilities High-level change over plan/philosophy Cleaning Validation and acceptance criteria Actual changeover batch records A good documentation package is critical when it comes to successful inspections

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Optimal Reliable Retrofit Design of Multiproduct Batch Plants

Mar 19, 2004  The problem of the retrofit design of a multiproduct batch plant is considered from a new perspective that involves explicit consideration of inherent reliability and maintainability characteristics of existing and new equipment. Until now, in multiproduct batch plant retrofitting formulations, the production capacity has been specified by the limiting batch size and limiting cycle time. We ...

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Modeling Demand Uncertainty and Processing Time ...

1.1 Multiple - Product Batch Plants 1 1.2 Types of Campaigns 1 ... 2.1 Process Design 4 2.2 Scheduling Multi-Product Plant 5 2.2.1 Unlimited Storage and Zero Wait Policies 5 2.2.2 Finite Intermediate Storage 5 2.3 Single Product Campaign 5 2.4 Mixed Product Campaign 5 ...

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Plant-wide Control

Multiple Product Batch Plants. Single Product Campaigns (SPC) Cycle time A = 5 hrs, Cycle time B = 4 hrs. CT. A+B = 9 hrs (To repeat AABB)Makespan (2 batches) = 20 hrs. First finish production of all batches of any one product, then start the second. For two batches, AA-BB

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Dynamic optimization in the design and scheduling of ...

Jul 01, 1996  Dynamic batch processing provides additional transient operating freedom, that can stretch the limits of profitability under strict market, facility, and time constraints. The paper incorporates dynamic processing conditions for products in a multiproduct batch plant, as opposed to fixing the ...

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Optimal design of multipurpose batch facilities with ...

Recently a review on the design of batch plants was performed by Barbosa-Póvoa (2007) where both the grassroots and the retrofit design problems are analysed for both multi-product and multipurpose plant types, and limitations and gaps are discussed. The three aforementioned frameworks that can be used in optimal design of multipurpose batch ...

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Multiperiod design and planning of multiproduct batch ...

Sep 01, 2009  This work presents a multiperiod optimization model for multiproduct batch plants operating during several time periods with different characteristics because of seasonal and market fluctuations. This model simultaneously considers decisions about the design, operation, scheduling, and planning of the plant and the corresponding trade‐offs among them. Thus, decomposition

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Optimization of a biotechnological multiproduct batch ...

The design of multi-product batch plants using an optimization-based approach has been studied for more than 40 years and different approaches to deal with the complexity of the optimization models that result in non-convex mixed-integer non-linear problems (MINLP) goes from the development of new

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Flexible retrofit design of multiproduct batch plants ...

We treat the addition of new equipment to an existing multiproduct batch plant for which new production targets and selling profits have been specified. This optimal retrofit design problem has been considered by Vaselenak et al. (Ind. Engng Chem. Res. 26, 718-728, 1987).

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Multiperiod design and planning of multiproduct batch ...

Jul 16, 2009  This work presents a multiperiod optimization model for multiproduct batch plants operating during several time periods with different characteristics because of seasonal and market fluctuations. This model simultaneously considers decisions about the design, operation, scheduling, and planning of the plant and the corresponding trade-offs ...

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Optimization of Multiproduct Batch Plant Design for ...

Optimization of Multiproduct Batch Plant Design for Protein Production Using Gradient Boosting Algorithms Youness El Hamzaoui 1* , Juan Antonio Álvarez Arellano 2 This work deals with the problem of modeling and prediction of compressive strength of concrete structure in multiproduct batch plant design of protein production found in a chemical ...

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A multiperiod model for production planning and design in ...

A general multiperiod model to optimize simultaneously production planning and design decisions applied to multiproduct batch plants is proposed. This model includes deterministic seasonal variatio...

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Optimal design of multipurpose batch facilities with ...

Recently a review on the design of batch plants was performed by Barbosa-Póvoa (2007) where both the grassroots and the retrofit design problems are analysed for both multi-product and multipurpose plant types, and limitations and gaps are discussed. The three aforementioned frameworks that can be used in optimal design of multipurpose batch ...

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Multiobjective optimization for multiproduct batch plant ...

This work deals with the multicriteria cost–environment design of multiproduct batch plants, where the design variables are the size of the equipment items as well as the operating conditions. The case study is a multiproduct batch plant for the production of four recombinant proteins.

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Discrete simulation in the design, layout and scheduling ...

aspects of safety in the design of computer-controlled pipeless plants: process, computer-control, and schedule. Some of the issues concerned with process safety have been described elsewhere7, and would pick up problems with cross-contamination, double-charging etc. in the same way as in a conventional multi-product batch plant.

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Wonderware InBatch

facilitate the design and implementation of systems that are compliant with FDA 21 CFR Part 11 regulations. SUMMARY Wonderware InBatch software effectively manages flexible, multi-stream and multi- product batch operations found in the process industries. BUSINESS VALUE InBatch software is a flexible batch ... A batch processing plant is made ...

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Multiproduct batch plants design using linear process ...

Jan 01, 2011  Multiproduct batch plants design using linear process performance models Moreno, Marta S.; Montagna, Jorge M. 2011-01-01 00:00:00 In this contribution, a novel linear generalized disjunctive programming (LGDP) model is developed for the design of multiproduct batch plants optimizing both process variables and the structure of the plant through ...

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Converting from Single to Multi Product Production Lines

Jun 08, 2012  Automation, June 2012 By Bill Lydon, Editor Participants of the Pharmaceutical Automation Roundtable discussed the conversion of production lines from single product to multiproduct, which ultimately creates flexible manufacturing pharmaceutical plants. This is

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Ecodesign of Batch Processes: Optimal Design Strategies ...

environment design of multi-product batch plants, where the design variables are the plant configuration with equipment item sizes and parallel equipment number as well as the operating conditions. This article is organized as follows. Section 2 presents the general framework.

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Batch Distillation - SlideShare

Oct 16, 2013  With the widespread use of batch stills in multi-product plants it is rare for a new design to be undertaken without some prior experience of performing the separation on a trial campaign. Thus the design and mode of operation of many existing batch stills has evolved on a empirical basis with only limited reference to conventional distillation ...

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